In humans, polydactyly (i.e. presence of extra fingers and toes) is determined by a dominant autosomal allele (P) and the normal condition is determined by a recessive allele (p). Find out the possible genotypes of family members 1, 2 and 3 in the given pedigree.

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Pedigree analysis provides information regarding inheritance of particular traits or diseases and using it we can predict the possibility of appearance of any traits in the new generation.

Member 3 is unaffected and the normal condition is recessive thus its genotype will be pp. To obtain recessive homozygous condition, both parents must have the recessive allele, therefore, member 2 must be heterozygous as it is affected one. Genotype of member 2 is Pp.

Member 1 genotype is also Pp as the son is unaffected (pp) and the wife of member 1 is normal.

$1$	$2$	$3$
$P P$	$P p$	$p p$

$1$	$2$	$3$
$P P$	$P P$	$p p$

$1$	$2$	$3$
$P p$	$P P$	$P p$

$1$	$2$	$3$
$P p$	$P p$	$p p$

Zoology - Principles of Inheritance and Variation Question with Solution | TestHub

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