While studying an autosomal recessive disorder in a family, it was noted that husband and wife both did not suffer from the disease but their fathers had the disease. What is the probability that the

Question

While studying an autosomal recessive disorder in a family, it was noted that husband and wife both did not suffer from the disease but their fathers had the disease. What is the probability that the couple will have a girl child without the disorder?

TestHub · Accepted Answer

Husband and wife are heterozygous as they don't suffer from autosome recessive disorder but their fathers were suffering from it. Their phenotype is Aa. The cross Aa x Aa produces children in the ratio AA:Aa:aa = 1:2:1. The probability of having a child without disorder Aa or AA will be 3 4 . The probability of having a female child is 1 2 . The probability of having a female child without disorder is 3 4 x 1 2 = 3 8.

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