Zoology - Molecular Basis of Inheritance Question with Solution | TestHub

DNA replicates semi conservatively. It was shown first inEscherichia coliand subsequently in higher organisms, such as plants and human cells. Matthew Meselson and Franklin Stahl performed the experiment in 1958. They grewE. coliin a medium containing¹⁵NH₄Cl (¹⁵N is the heavy isotope of nitrogen) as the only nitrogen source for many generations. The result was that¹⁵N was incorporated into newly synthesised DNA (as well as other nitrogen-containing compounds). This heavy DNA molecule could be distinguished from the normal DNA by centrifugation in a caesium chloride (CsCl) density gradient.