Zoology - Molecular Basis of Inheritance Question with Solution | TestHub
Which among the following statements are correct?
(i)rich regions of DNA denature at low temperature and are less stable thanrich regions.
(ii) RNA is more stable than DNA.
(iii) SNPs are present at about 1 billion locations in humans.
(iv) DNA polymerase I have bothandexonuclease activity.
(v) Rifampicin inhibits RNA synthesis by inhibiting RNA polymerase.
Options:
Answer:
Solution:
SNP or single nucleotide polymorphism is a mutation where a single nucleotide is substituted at specific location. They are found to occur once in every 300 nucleotides on average. Around ten million SNPs are there in the human genome.
DNA sequences rich in G-C are more stable than with A-T rich sequences. The stability is due to stacking interactions called base stacking than hydrogen bonding.
Rifampicin is an antibiotic that is used in preventing bacterial infections. It works by inhibiting RNA polymerase which in turn blocks protein synthesis in bacteria.
DNA polymerase I is a biocatalyst involved in DNA replication process. This enzyme has exonuclease activity in both directions (and).
DNA is the nucleic acid that forms the genetic material in all organisms. The structure of deoxyribose nucleic acid was elucidated by Watson and Crick. The DNA is a double helical structure having two anti-parallel strands of polynucleotide chains joined to each other by hydrogen bonding formed between the N-bases. It is more stable than ribonucleic acid (RNA) as it has thymine (5-methyl uracil) which has greater resistance to photochemical mutation and deoxyribose (less reactive than ribose).
