Zoology - Human Health and Diseases Question with Solution | TestHub
Which of the following statements about HIV is/are correct?
A. HIV makes a copy of DNA from its RNA genome using enzyme reverse transcriptase.
B. HIV kills the macrophages it infects.
C. The genome of HIV comprises of two single-stranded RNA.
D. HIV causes depletion of helper T lymphocytes, due to which the person starts suffering from infections that would have been otherwise overcome; such as those due to bacteriaMycobacteriumand other parasites.
Options:
Answer:
Solution:
Attacking the macrophage HIV reservoir has proven a thornier issue. From the virus's standpoint, macrophages are an ideal reservoir cell because they are long-lived, because HIV does not kill macrophages by direct lysis, as it does CD4+T cells, and because virus production by chronically infected macrophages tends to be relatively insensitive to a variety of antiretroviral agents. Besides hosting a significant virus reservoir, chronically infected macrophages and/or their brain counterparts, microglia, may contribute to pathogenesis through the chronic aberrant release of a variety of host and viral cytoactive factors and may be subject to chronic dysregulation through the aberrant expression of surface receptors.
