Zoology - Excretory Products and their Elimination Question with Solution | TestHub

Urea biosynthesis takes place in mitochondria where urea cycle enzymes are located. Urea biosynthesis is a cycle of biochemical reactions that produces urea from ammonia. This cycle occurs in ureotelic organisms. The urea cycle converts highly toxic ammonia to urea for excretion. This cycle was described by Krebs-Henseleit. The liver is the site of urea synthesis. The urea cycle consists of five enzymatically controlled steps that are catalyzed by carbamoyl phosphate synthetase, ornithine transcarbamylase, argininosuccinate synthetase, argininosuccinase, and arginase, respectively. The first 2 steps- formation of carbamyl phosphate and formation of citrulline are taking place in the mitochondria.