Two enzymes responsible for restricting the growth of bacteriophages in E.coli were isolated. One was methylase and other was a restriction endonuclease. What is the significance of methylase?

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The host DNA is protected by other enzymes called methylases, which methylate adenine bases within host recognition sequences. For each restriction endonuclease, the host cell produces a corresponding methylase that marks the host DNA and prevents its degradation. These pairs of enzymes are referred to as restriction-modification systems.

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