Which of the following is CORRECT match.
Column I Column II
$(A)$ ADA - deficiency $(i)$ $α - 1$ antitrypsin
$(B)$ Emphysema $(i i)$ Bone marrow transplanation
$(C)$ Insulin $(i i i)$ Diabetes mellitus
$(D)$ Insect resistance $(i v)$ $T_{i}$ - plasmid

Question

Which of the following is CORRECT match.

	Column I		Column II
$(A)$	ADA - deficiency	$(i)$	$α - 1$ antitrypsin
$(B)$	Emphysema	$(i i)$	Bone marrow transplanation
$(C)$	Insulin	$(i i i)$	Diabetes mellitus
$(D)$	Insect resistance	$(i v)$	$T_{i}$ - plasmid

TestHub · Accepted Answer

The first clinical gene therapy was given for treating Adenosine deaminase deficiency. It was conducted at Maryland in 1990 on a four year old girl .She was suffering from ADA deficiency. This enzyme is important for formation of immune system in the body. Hence biotechnology principles were applied to treat this condition. A functional ADA gene was introduced ex vivo in the marrow cells through a vector which had functional ADA gene. The treated cells were reintroduced into the patient's marrow.
Emphysema is a condition that affects the respiratory system and the risk increases by deficiency of alpha -1- antitrypsin.
Insulin is a hormone that is responsible to maintain the glucose levels and lack of it will cause diabetes mellitus.
Ti plasmid is used as a vector to induce insect resistance in plants.

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