The best combination of reagents for synthesis of Ph − O − CH 2 − CH 3 by williamson synthesis.

Question

The best combination of reagents for synthesis of Ph − O − CH 2 ​ − CH 3 ​ by williamson synthesis.

TestHub · Accepted Answer

The Williamson ether synthesis proceeds via an Sɴ2 mechanism; therefore, a primary alkyl halide is most suitable.

To synthesize the ether Ph–O–C₂H₅, the nucleophile should be the phenoxide ion (PhO⁻).

This is reacted with ethyl bromide (EtBr).

Hence, the correct combination is (B) EtBr + PhO⁻.

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