Chemistry - Carboxylic acid and their Derivatives Question with Solution | TestHub
The compound which undergo nucelophilic substitution fastest would be :
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Answer:
Solution:
Question Explanation:
The question asks which of the given acyl compounds undergoes nucleophilic substitution at the fastest rate.
Concept:
This question is based on the reactivity order of carboxylic acid derivatives.
Solution:
The rate of nucleophilic substitution depends on the electrophilicity of the carbonyl carbon and the leaving group ability.
Acid halides (–COCl) are the most reactive acyl derivatives because chlorine has a strong –I effect, increasing the positive character of the carbonyl carbon.
Additionally, Cl- is a good leaving group, facilitating rapid substitution.
General reactivity order: Acid halide > Anhydride > Ester > Amide. Ketones do not undergo nucleophilic substitution reaction.