Chemistry - Biomolecules Question with Solution | TestHub

The reduction of activity of succinate dehydrogenase by malonate is an example of competitive inhibition. Competitive inhibition is a reversible inhibition where inhibitor competes with the normal substrate for the active site of the enzyme. A competitive inhibitor is usually similar to the normal substrate and, therefore, fits the active site of an enzyme and binds with it. Since a competitive inhibitor occupies the site only temporarily, the enzyme action is not permanently affected. Thus, addition of a lot of succinate can reverse the inhibition of succinic dehydrogenase by malonate.