Chemistry - Biomolecules Question with Solution | TestHub
Mark the correct option about prosthetic group and co-enzyme.
| Prosthetic group | Co-enzyme | |||
| Nature | Mode of action | Nature | Mode of action | |
| (i) | organic | Tightly binds to protein part of the enzyme | inorganic | Transient association with protein part of the enzyme |
| (ii) | inorganic | Transient association with protein part of an enzyme | organic | Tightly binds to protein part of an enzyme |
| (iii) | organic | Tightly binds to protein part of the enzyme | organic | Transient association with protein part of the enzyme |
| (iv) | inorganic | Transient association with protein part of an enzyme | inorganic | Tightly binds to protein part of an enzyme |
Options:
Answer:
Solution:
Prosthetic groups are organic compounds and are distinguished from other cofactors in that they are tightly bound to the apoenzyme. For example, in peroxidase and catalase, which catalyze the breakdown of hydrogen peroxide to water and oxygen, haem is the prosthetic group and it is a part of the active site of the enzyme. Co-enzymes are also organic compounds but their association with the apoenzyme is only transient, usually occurring during the course of catalysis. Furthermore, co-enzymes serve as co-factors in a number of different enzyme catalyzed reactions. The essential chemical components of many coenzymes are vitamins, e.g., coenzyme nicotinamide adenine dinucleotide (NAD) and NADP contain the vitamin niacin. Catalytic activity is lost when the co-factor is removed from the enzyme which testifies that they play a crucial role in the catalytic activity of the enzyme.
