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Oxygen dissociation curve

When percentage saturation of haemoglobin with${\mathrm{O}}_2$is plotted against the${\mathrm{p}\mathrm{O}}_2$, a sigmoid curve is obtained which is termed as Oxygen dissociation curve. Utility: This curve is highly useful in studying the effects of various factors (like${\mathrm{p}\mathrm{C}\mathrm{O}}_2$,${\mathrm{H}}^{+}$concentration, etc.) on the binding of${\mathrm{O}}_2$with haemoglobin. Factors that are favourable in the tissues for the dissociation of oxyhaemoglobin shifting the curve towards the right: Low${\mathrm{p}\mathrm{O}}_2$, high${\mathrm{p}\mathrm{C}\mathrm{O}}_2$, greater${\mathrm{H}}^{+}$concentration and higher temperature