For packing of a negatively charged DNA, a positively charged histone molecules rich in basic amino acids are required. This histones are formed during:

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Howard and Pelc (1953) have divided cell cycle into four phases or stages, i.e., $G_{1}$ , S, $G_{2}$ and M-phase. The $G_{1}$ -phase, S-phase, and $G_{2}$ -phase are combined to form the interphase.

$G_{1}$ -phase It involves transcription of t-RNA, m-RNA and r-RNA synthesis of regulatory proteins, enzymes necessary for DNA synthesis, tubulin and other mitotic proteins. The $G_{1}$ -phase where differentiated somatic cell arrested is called $G_{0} - P h a s e .$

S-Phase During S-phase replication of DNA and synthesis of histone proteins occur.

$G_{2} - P h a s e$ Synthesis of RNA and proteins continue, which are required for cell growth.

Botany - Cell Cycle and Cell Division Question with Solution | TestHub

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