Biology - Principles of Inheritance and Variation Question with Solution | TestHub

BiologyPrinciples of Inheritance and VariationGenetic DisordersMedium2 minPYQ_2026
BiologyMediumsingle choice

Match the disorders inList Iwith their causes inList IIand choose the correct option.

List IList II
(A) Thalassemia.(I) non-disjunction of sex chromosomes.
(B) Sickle-cell anaemia.(II) non-disjuction of 21st pair of chromosomes.
(C) Turner's Syndrome.(III) Synthesising few globin molecules.
(D) Down's Syndrome.(IV) synthesising an incorrectly functional globin.

Options:

Answer:
D
Solution:

Thalassemia is a quantitative blood disorder that results in the synthesis of too few globin molecules. Thus, (A) matches (III).

Sickle-cell anaemia is a qualitative blood disorder that results in the synthesis of an incorrectly functioning globin molecule. Thus, (B) matches (IV).

Turner's Syndrome is caused by the absence of one of the X chromosomes ( with ), which occurs due to the non-disjunction of sex chromosomes during gametogenesis. Thus, (C) matches (I).

Down's Syndrome is caused by the presence of an additional copy of chromosome number (trisomy of ), which occurs due to the non-disjunction of the st pair of chromosomes. Thus, (D) matches (II).

The correct matching is (A) - (III), (B) - (IV), (C) - (I), (D) - (II).

Answer: (A) - (III), (B) - (IV), (C) - (I), (D) - (II).

Stream:MHT_CET_MEDICALSubject:BiologyTopic:Principles of Inheritance and VariationSubtopic:Genetic Disorders
⏱ 2mℹ️ Source: PYQ_2026

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