Biology - Neural Control and Coordination Question with Solution | TestHub

Synaptic fatigue is the temporary inability of a synapse to transmit a nerve impulse.

When a presynaptic neuron is stimulated continuously at a high frequency, the neurotransmitter vesicles in the presynaptic terminal are released rapidly.

If the rate of release of the neurotransmitter exceeds the rate of its synthesis and reuptake, the neurotransmitter gets depleted or exhausted.

This exhaustion of the neurotransmitter temporarily stops the transmission of nerve impulses across the synapse until the neurotransmitter is replenished.

Answer: exhaustion of its neurotransmitter