Biology - Chemical Coordination and Integration Question with Solution | TestHub
Which of the following is NOT a symptom of Cushing's disease?
Options:
Answer:
Solution:
Cushing's disease is caused by the hypersecretion of cortisol (a glucocorticoid) from the adrenal cortex.
Excess cortisol leads to increased gluconeogenesis, which can cause hyperglycemia and subsequently glucosuria. It also causes a redistribution of body fat, leading to truncal obesity, a 'moon face', and a 'buffalo hump'.
Cortisol has weak mineralocorticoid activity, which promotes sodium retention and potassium excretion in the kidneys. This sodium retention leads to increased blood volume and high blood pressure (hypertension).
Since sodium is retained in the body, its excretion in urine decreases. Therefore, natriuresis (excessive loss of sodium in urine) is not a symptom of Cushing's disease.
Answer: Natriuresis
